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ChronWeasely t1_j0omyk1 wrote

Reply to comment by 090810290202 in Cambridge scientists have shown that a widely-used drug to treat liver disease can prevent SARS-CoV-2 infection or reduce COVID-19 severity by hot

Must have to do with stability. The basic delivery mechanism is not uncommon for new mRNA treatments. One of several. Lipid stabilization, which lets it enter cells by just merging with cell walls, which are also lipid, and dumping the mRNA inside. As the mRNA doesn't need to go any further in the cell, that's all that's needed.

Some more complicated ones have several components to navigate each part of the delivery mechanism.

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090810290202 t1_j0pe453 wrote

Indeed! I believe the narrative was that Pfizer/BioNTech tried out 3 or maybe 4 mechanisms in clinical trials and ultimately went with the one patented by Moderna.

I assume they utilized different adjuvants and strengths.

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