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messopotatoesmia t1_j2qec1n wrote

Reply to comment by Zestfullyclean87 in A study on obese patients suggests the gut microbiome affects obesity levels. Microbial diversity decreased in obese subjects, and the reduction trend was correlated with the severity of obesity. by glawgii

That's pretty much the definition of satiating. It sates the urge.

I grew up in another country. Got much fatter once I was here. And chicken bone broth makes me rapidly satiated; even foods cooked in it. I eat it, my hunger gives way rapidly to feeling annoyingly full in about 1/4 the quantity it would normally take. My theory is that it's rich in L-Glutamine, calcium and magnesium, and that's enough to trip the mechanism and to provide enough raw precursors for the gut lumen to generate GLP-1 in large quantities, a bit like semaglutide, but that's just a hunch.

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Zestfullyclean87 t1_j2qj6yx wrote

So you think being satiated forces a person to put the food down?

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messopotatoesmia t1_j2qqv52 wrote

Unless they have a busted ventromedial nucleus of the hypothalamus, yes.

If that's shot, they'll eat until they burst, but that's very unlikely - though the cause might be glutamate toxicity.

It might happen with people with poor gut barrier function if they consume a lot of wheat; wheat-germ agglutinin (WGA) binds leptin receptors, blocking them. Leptin inhibits hunger. Similarly, WGA also binds insulin receptors, so it's a bit of a double whammy; it takes the brakes off hunger and increases blood glucose, causing it to be more likely to be stored as fat. Regardless, hunger increases.

You seem to be quibbling over the definition of satiety. Satiety means "feels full/done with food". By definition, if someone experience satiety, their hunger is sated, and stops.

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