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A link to the study:

https://onlinelibrary.wiley.com/doi/10.1111/acel.13773

>. Functional assessment of human OA chondrocytes showed the acquisition of progenitor-like immature phenotype by a significant subset of cells. Finally, conditional deletion of Stat3 in cartilage cells increased DNMT3B expression in articular chondrocytes in the knee joint in vivo and resulted in a more prominent OA progression in a post-traumatic OA (PTOA) mouse model induced by destabilization of the medial meniscus (DMM). Taken together these data reveal a novel role for STAT3 in regulating DNA methylation in cartilage development and disease. Our findings also suggest that elevated levels of active STAT3 in OA chondrocytes may indicate an intrinsic attempt of the tissue to regenerate by promoting a progenitor-like phenotype. However, it is likely that chronic activation of this pathway, induced by IL-6 cytokines, is detrimental and leads to tissue degeneration.

Hope so, I got it in my knee it can hurt like a mofo

There's also a bi-partisan agreement in Congress for medicinal marijuana to relieve arthritis pain.

In other words, there is joint support for joint support for joint support...

I'll smoke a joint to that!

Sounds promising until that last part.

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That's some joint-up thinking right there.

Has anyone tried hyaluronic acid supplements?

Big Hyaluron hates this one simple trick.

Had them done in both knees. Worked for about 2 months in right knee( car accident) left one is doing ok but it was the worse of the 2 ( osteoporosis)

Yes. I’ve had a couple rounds of injections in a knee. It works short term, which is nice if I know of a specific activity coming up or something. But I don’t get more than 45(ish) days of relief. I’m not sure I’ll get another one, I’m not sure the juice is worth the squeeze. I’m pretty tender for a few days after, it’s a giant needle after all.

Don't you mean Big Surgery?

After all, I've heard (anecdotal, can't say it really did unless I speak to the person who underwent it) of it's success in deferring the need for knee replacement surgery, thereby saving them potentially thousands of dollars.

No but I got the injections and had a really negative experience. It's extremely anecdotal but I had chronic pain increased from the injections when they were supposed to do the opposite.

Everything that I read prior to getting them stated neutral or positive effects. I guess I'm lucky.

>Unfortunately, while these immature cells make cartilage that is youthfully regenerative during embryonic development or acute injury, they seemed to create cartilage that is dysfunctionally immature in the context of a chronic condition such as osteoarthritis.

>“When present on a longer term basis, hyperactivation of the immature program in cartilage cells is likely to promote inflammation and, ultimately, degeneration and fibrosis,” said Liu, a senior scientist in the Evseenko Lab.

That's a very big caveat that people should be aware of the research. This is extremely early and it is serving as a foundation for others to build work upon. You won't have this anytime soon (like 10 years + in a best case scenario).

Is that located in the junk not junk parts of the dna?

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> Big Hyaluron

Sauron's slightly dumb brother?

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