A direct link to the journal for those who are interested:

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800490

Key Points:

>Question Does body weight modify metabolism and response to vitamin D supplementation?
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>Findings In this cohort study, a subset including 16515 participants of the VITAL randomized clinical trial, established and novel vitamin D serum metabolite levels were on average lower at higher body mass index. Supplementation increased vitamin D levels less over 2 years at higher body mass index.
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>Meaning Previous trials observed reduced efficacy of vitamin D supplementation for outcomes of cancer, diabetes, and others, in subsets of participants with higher body mass index; the findings of this cohort study suggest this may be due to a blunted metabolism and internal dose at higher body weights.