Chronotaru t1_j5f0kf7 wrote
What's I'd most like to know is how the mania with those who had problems progressed over a longer period, say a couple of months. If the psilocybin helped eliminate or reduce the depression aspects, the mania went no mania for a week, increase in mania for another week or two, then balance back to what it was before the experience while the depression is still either gone or better then I would count that as a win. Meanwhile if the mania is still heightened after two months then that might be hard to justify even if the depression aspects were reduced.
The full holistic picture is rarely possible to obtain from any of these studies with the focus on quantitative data.
ifitfartsitsharts t1_j5g9d5z wrote
Problem is, when people have a manic episode, their judgment is severely compromised and they can ruin their lives in days (gambling, risky behaviors, medical effects). Some people will spend all of their money during an episode and ruin themselves financially. So even if the absolute risk of having a manic episode is low, the consequences of having one can be catastrophic. Theres no insurance for unintentionally ruining your life (non-medically) while having a manic episode.
Chronotaru t1_j5gai9l wrote
People who have bipolar one already have manic episodes. A very temporary increase isn’t adding anything new, it’s making their lives more difficult for a while in which they might mean they need more support in that window. In a hypothetical scenario it might even be worthwhile to be an inpatient for a week to ride it out of there was a payoff.
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