The critical thing to note about usage of serotonergics or dopaminergics when recommending their use for treatment is that people's baseline levels of those neurotransmitters, their receptor sensitivity, and theirability to convert/process precursors metabolically into active substances can vary wildly depending on a number of different pathological and developmental factors. Just as with anti-depressants, marijuana and psilocybin can be radically detrimental to individuals with specific conditions, and its use can result in real harm to those people

No medicine is beneficial every time, at every dose, to every person. Everything has it's drawbacks and diagnosis considerations, and safer administration protocols with proper harm reduction controls do exist and can be utilized, even in a non-clinical setting.