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ToHallowMySleep t1_ja35hdg wrote

Reply to comment by Surur in Man successfully performs gene therapy on himself to cure his lactose intolerance by [deleted]

Summary for those who don't want to watch the whole thing: the effects wore off slightly over time, but he is down to a more normal level of lactose intolerance, as opposed to the extreme level he was before. So there is still long-term benefit.

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[deleted] OP t1_ja39tux wrote

This was expected. Gene therapy isn't necessarily permanent.

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Nervous-Newt848 t1_ja5tzzs wrote

Probably didnt do it right and it is supposed to be somewhat permanent... I will say cells can accumulate dna mutations over time due to environmental factors and faulty dna replication... Idk if 5 years is long enough... He probably didnt have enough dna editing viral vector

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Nervous-Newt848 t1_ja5uxie wrote

Gene therapy is as permanent as it gets... It may not necessarily be permanent because of the epigenome and because of poor dna replication... Dna replication isnt 100% accurate

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AwesomeDragon97 t1_ja62k4q wrote

Not all cells in the body are affected so it’s likely that the cells that got the gene died and were replaced by cells without the gene.

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