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Homie4-2-0 OP t1_j1z8bky wrote

Reply to comment by Babelette in LifT Bioscience - Cure for Cancer by Homie4-2-0

From what I recall, there was a safety trial involving granulocytes in terminally ill patients, and it resulted in tumors shrinking up to 80%. This was done with a low dose of a weaker neutrophil than what they're using. I usually don't post much about cancer because of the concerns you addressed, but all the data I've seen from them and the universality of the treatment leave me optimistic.

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Babelette t1_j1z8wmk wrote

Considering that the bar for NDAs is extending life by a few months or years, it could definitely go through.

Shrinkage isn't a cure through. I think over time cancer will become a chronic managed illness like diabetes or HIV.

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Homie4-2-0 OP t1_j1zcty6 wrote

Keep in mind that those results were with a safety dose of a weaker version of the neutrophils they're currently using. Their mouse studies with stronger neutrophils and higher dosing resulted in 100% survival rates and tumor elimination. What the safety study does prove is that the mechanism of action works the same way in humans as in mice. It also proves safety. That's why I think they have a pretty good chance of succeeding. Of course, biotech is a field riddled with failure, so I may very well be wrong, but I'm optimistic. Luckily, we'll only have to wait a couple of years before we know if it works.

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Blackmail30000 t1_j1zcjsn wrote

perhaps a recurring issue on the seriousness level of recurring eczema. something that keeps popping up, but easily cleared up.

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AsuhoChinami t1_j22ihgy wrote

I'm optimistic too. For what percentage of people was that granulocyte safety trial effective for? If it could be re-administered repeatedly, wouldn't that just make the cancer a chronic condition rather than something resulting in death?

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Homie4-2-0 OP t1_j22vjhc wrote

I managed to find the original study for you. It worked in all patients, although it was a small study. They do plan on re-administration. Treatment will involve getting an infusion every 4-5 days until the cancer is gone. They expect about 6-8 infusions in total. Keep in mind that this treatment results in immune memory of the cancer, so you won't need chronic management. Also, since posting this, I found another presentation from the company where they went into detail about the methodology of their organoid models. Those results were observed from direct killing only and with only one infusion.

https://www.sciencedirect.com/science/article/pii/S2405844017316936

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