Here is the company’s own article.

Their key innovation is using glutaraldehyde for brain preservation. The article is worth reading. They argue that long term memory is made possible not by the electrical pattern of the brain, or any individual neuron, molecule, or synapse, but rather by the overall structure that these constituents form. From the Nectome’s article:

>Glutaraldehyde reacts rapidly with tissue to form a densely crosslinked, stable gel-like form which can withstand major changes in pH, temperature, osmotic stress, and other ordinarily destructive insults. Virtually all proteins and mRNAs can be labeled and analyzed after aldehyde fixation. (…) Taken together, clinical, neuroscientific, and biochemical evidence suggests that glutaraldehyde fixation comprehensively preserves the information that encodes an organism’s long-term memories. (…) Glutaraldehyde fixation is so comprehensive that it allows differentiation between even slight differences in mRNA, protein distribution and nano structural changes at a single synapse, or changes in gene expression in a single neuron. These minor differences are far below the level of physical changes which would be behaviorally observable in a living organism [, and still not interfere with memory preservation, such as ischemia, deep hypothermic circulatory arrest, concussions, anesthetic, MRI scans]. In summary, the signal the nervous system employs to create a long-term memory (robust self-perpetuating biochemical changes at multiple synapses) is greater than the noise introduced by glutaraldehyde fixation (which can preserve even functionally irrelevant changes at a single synapse).