I doubt we’re going to have fully simulated worlds, or at least I doubt that’ll be the norm. I think it’s more likely that an ASI will simply imagine how the world would be, and predict the results of certain actions and then display them, rather than simulate a world in its entirety. Doing so would require many orders of magnitude less processing power for a nearly equivalent experience. Therefore, since I believe that since these worlds will only be imagined, doing anything to people in these worlds would not matter morally, since they do not actually have any consciousness.