How to Prepare for the AI Assisted Life Extension Escape Velocity

Submitted by banuk_sickness_eater t3_104z78s in singularity

This is a recommendation, not an advertisement. If anyone else has any recommendations for preparing for AI-assisted life extension escape velocity, please share.

One way I've prepared is using Nebula's Whole Genome Sequencing services.

I recommend everyone do the same and opt for the Ultra Deep Whole Genome Sequence.

It's much more expensive, but far more comprehensive than the other options, particularly because it offers a full mapping of your genetic proteome, which could be crucial for future rejuvenation therapies. They also return all of the information in raw and clean data formats for your personal storage, which could be vital in providing a baseline for future computational gene therapists to work from.

If you are young or in good health, my recommendation is to do this sooner rather than later. Each day that passes, you are a day older and just that much more susceptible to irreversible gene expression changes.

The hope is that this data will provide a "save state" for future computational gene therapists to rejuvenate your DNA in the event of irreversible gene damage, deterioration from aging, or gene expression changes. This means that if you do this when you are 30 and it takes until you are 60 for gene rejuvenation technology to mature to the point of viability, you could return your genes to the biological state they were in when you were 30, effectively making you 30 again.

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Comments

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SteelCatamaran t1_j38bh21 wrote

Fascinating idea. My initial thought is the question on how valuable a save state will be, The other idea could be that your current DNA may be decoded later then AI determines changes in code that will be more beneficial than a previous save state and goes with that. You may even could select the modification level.

This all assumes continued alignment to a narrow idea of human service.

I know most of us have an instinct to survive that is healthy, but I have grown to also appreciate the physical time limits on the human body as well. If I was stuck in a single lifetime forever, it would lead me to create a simulation that allows me to become other lives with memory isolation and simulated death with reincarnations. (To spice things up a bit until that simulation reaches simulated life expectancy escape velocity again). I do like the idea of selectively accessing the individual lifetimes later in a higher level state as I long for connection, but also need variation.

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ElvinRath t1_j38d6gc wrote

I'll take a look at the comments here.

I'm not sure if this would make much sense. I mean, I think that if information that specific is needed, probably the treatment will be so expensive that I can't pay it anyway...

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I had the feeling that this kind of tech only will be really available for anyone if it gets very cheap because it can be mass produced, either because it is a general treatment, or because it can get personalized very easily, in an automated way...

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But honestly I have not read too much about it. I usually asumed that this was something that we would not get by ourselves, just something that if we are lucky and build a very powerfull AI maybe it can get for us.

So I don't really have an idea of how the field is going right now.

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userbrn1 t1_j397vpj wrote

I'm skeptical of your claim that this is better to get now than later. You say that the present day expression can be a "save state", but from my understanding your genome is pretty static throughout your life, save for telomeres. Expression changes over time, but it is much more likely sounding to me that there are general proteomic changes associated with aging that are pretty standard in the population, and can be targeted with much more accuracy in a each passing decade.

I think it would probably be more worthwhile to do one of these in 5 years, when the same product will cost $100 instead of $1000.

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banuk_sickness_eater OP t1_j39gilm wrote

Replying to [deleted] (#1,298,534)

Perhaps, the future holds many unknown unknowns. This is merely insurance in case repairing your genes is costlier or less effective than simply returning your genome to a specific save state.

Rather than an AI guessing what information has been lost as your genes deteriorate with age, it may be simpler and cheaper to just reintroduce an intact version that information.

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banuk_sickness_eater OP t1_j39km6e wrote

Replying to userbrn1 (#1,298,618)

Although the genome is largely static throughout an individual's life, there are a few mechanisms that can lead to changes in the genome. One mechanism is mutation, which is a change in the DNA sequence that can occur as a result of errors during DNA replication or exposure to certain environmental factors, such as radiation (not just the via the likes of Polonium, think UV radiation) or chemicals. Mutations can result in changes to an individual's genetic makeup and can be passed down to future generations.

Another mechanism that can lead to changes in the genome is epigenetic modification, which refers to the process by which certain chemical modifications to DNA or to the proteins that DNA is wrapped around (called histones) can alter the expression of specific genes without changing the underlying DNA sequence. Epigenetic modifications can be influenced by a variety of factors, including diet, stress, and environmental exposures, and they can have an impact on an individual's traits and susceptibility to certain diseases.

So, while the genome is largely static throughout an individual's life, there are mechanisms that can influence it's mutation as you age, thus the recommendation to procure a "save state".

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Cryptizard t1_j39nw7c wrote

Replying to banuk_sickness_eater (#1,299,057)

  1. Commercial sequencing mashes together the DNA from thousands of cells, and your recommended "ultra" sequencing reads it 100 times meaning that any individual mutations will be eliminated.

  2. Epigenetics do not change the DNS that is sequenced so have nothing to do with your "save point."

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banuk_sickness_eater OP t1_j39pcjh wrote

Replying to Cryptizard (#1,299,161)

1.) The ultra sequencing I've recommended specifically searches for and reports on individual mutations including both coding and non-coding regions.

2.) DNA, as I assume you meant DNA, is the substrate for epigenetic regulation, and changes in the epigenetic marks on DNA can influence the expression of specific genes and have an impact on an individual's traits and susceptibility to certain diseases. Via high-throughput whole genome NGS, the ultra sequence also provides parsable insight into the epigenome.

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Babelette t1_j39y55b wrote

Nah, I want them good genes that AI comes up with.

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banuk_sickness_eater OP t1_j3a4o5u wrote

Replying to PolarsGaming (#1,299,487)

About $799, down from $1000 just a few years ago I think so depending on your situation it may be prescient to bookmark this and come back to it when the price falls further, just keep in perspective time's effect on the integrity of your genes.

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IntelligentBand467 t1_j3at7di wrote

I would rather get over my fear of death rather than try to live forever, not that one is better than another. But both are fine options.

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Loud-Mathematician76 t1_j3bfonf wrote

AKA. Easy guide on how to willingly DONATE your DNA to all the law enforcment agencies in the whole world!

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Desperate_Food7354 t1_j3bnfiq wrote

Replying to IntelligentBand467 (#1,300,581)

Good luck, if you have a strong cortex it’ll be much harder as you won’t be able to find the appropriate copium, but the best thing you can do is live to your fullest while it’s impossible to extend life dramatically currently, live as if life extension won’t occur, you have no other option.

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IntelligentBand467 t1_j3buhfd wrote

Replying to Desperate_Food7354 (#1,301,576)

I think the conclusion you draw is far from conclusive there. Living in fear vs. living in fear. And there is nothing that says fear needs to be the base from which all motivation and interest springs. I have many motivations that come from things other than fear. Anyway I'm not looking for an argument, and also I don't see anything wrong with trying to live longer or as long as possible.

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Desperate_Food7354 t1_j3bva4y wrote

Replying to IntelligentBand467 (#1,301,663)

I never said anything about not living longer, I think that’s a great idea, I’m just saying that death is very real and that I think we need this fear of death in order to conquer it if we are going to live such short lives in the first place. Say if Isaac newton decided to become the fastest pebble stacker for the first 70 years of his life and then all the sudden decided to do math, he wouldn’t of been Isaac newton, if he lived another 900 years there’s a good chance he’d still have been the person we knew if not way more.

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Loud-Mathematician76 t1_j3bvts3 wrote

Replying to banuk_sickness_eater (#1,301,372)

Sure makes sense. Don't rape, murder, burglarize or commit any other high level felonies. This applies today.

how will it be 5-10 years from now ? when the science evolves enough that testing availability increases and it starts being used for any single "offence" which you imagine.

let's say you drop a piece of litter on the street, boom they test it and you get fined or heck even jailed, who knows. Or you participate in a protest activity whatever, something the governement does not like and uses this somehow to track you and persecute ?

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