>As far as the human resource goes, we most likely would need to construct generational ships.

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You are absolutely correct,

The challenges, both practically and morally/ethically kind of boggle my mind though.

From a practical stand point how can we be sure that those born on board actually will stay the course? Will there be a mutiny? How will a baby born in space develop, physically and mentally?

What are the ethics of planning on having children born on a spaceship with the idea that they will have no agency, their who purpose is to live out their time driving a spaceship to another world.