I do wonder how interconnected to the planet we actually are, and won't really realise until people live off-Earth for long periods (i.e. years, maybe even decades).

Think of all the bacteria and tiny organisms we interact with on a daily basis. Like those in our soil, which end up in our food, which are crucial for plants to grow, the same plants that are proven to bring us well-being benefits.

Can we really live in a place that is essentially cut off from all the biodiversity that we evolved alongside? Sure, we can take soil and plants, and create little sanctuaries of Earth-nature, but it surely will always be nothing compared to a fully fledged ecosystem, let alone an entire planet.