Never. Solar Systems will be established, there will be travel, communication, and trade within those systems, but space is too big for a civilization like we have on earth. Travel between systems will take thousands of years, so there will be local systems, but flying around the galaxy all Willy Nilly will probably never happen. This is all if we don’t destroy ourselves. But hopefully I’m wrong and some wicked technology comes around that is economically efficient enough to allow the traversal of long distances similar to what airplanes do, but idk seems far fetched.