So I have been around the block a few times in terms of these kinds of decisions. What I have found is just about everything is the same everywhere in the US EXCEPT (but not limited to):

Cost of living/local government policies

Climate/geography/city environment (if you like to "get out" and do stuff, this matters.)

Specific jobs.

I just moved from FL to Springfield simply for the cost of living. FL is pretty top notch in terms of government/climate/jobs, but the cost of living sucks and Springfield has great compromises in all other areas. PLUS MO is centrally located in the US, so I can now drive (flying phobia) to other states like CO for vacations more easily.

What are the 2 jobs?