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H2AK119ub t1_ixuy1j6 wrote

Reply to comment by throwawayagain31 in Brain cancer vaccine succeeds at prolonging survival in Phase 3 trial by Sorin61

I don't really understand your points. Current IO therapies don't work in GBM because it is a very heterogenous tumor type (not clonal like heme is) and there are few T cells in the brain for the MOA of checkpoint inhibitors to work. TAM reeducation is the closest a generic, non-personalized IO therapy could have for a decent shot on goal in this indication.

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throwawayagain31 t1_ixv1cz0 wrote

Great points. I make some assumptions not really based in much research about glimpses just from personal experiences. You’re right in that it is a generic approach but it is wholly personalized from the POV that it’s utilizing the specific patient’s cells.

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