Viewing a single comment thread. View all comments

bored_in_NE t1_ixvhhlu wrote

"With well over 400 clinical trials for glioblastoma having failed over the last 15 years, it is gratifying to be able to offer new hope to patients who face this devastating disease."

This treatment offers a little more survival time but without the typical cancer treatment sideeffects.

In the Phase III trial of DCVax®-L, median Overall Survival (mOS) for newly diagnosed GBM patients (n=232) was 19.3 months from randomization (22.4 months from surgery) with DCVax-L vs. 16.5 months from randomization in the controls (HR=0.80, p=0.002). Survival at 48 months from randomization was 15.7% vs. 9.9%, and at 60 months was 13% vs. 5.7%. For recurrent GBM (n=64), mOS was 13.2 months from relapse vs. 7.8 months (HR = 0.58, p<0.001). Survival at 24 and 30 months post-recurrence was 20.7% vs. 9.6%, and 11.1% vs 5.1%, respectively. In newly diagnosed GBM patients with methylated MGMT, mOS was 30.2 months from randomization (33 months from surgery) with DCVax-L (n=90) vs. 21.3 months in controls (n=199) (HR=0.74, p=0.027).

EDIT: Removed line that was minimizing survival rate at 5 years.

30

DigitalParacosm t1_ixw0rz5 wrote

It’s more than doubling 5 year survival rates in the most common and fatal type of brain cancer. You cannot minimize these results.

23

PragmaticPanda42 t1_ixwtoby wrote

Thank you. High school boyfriend was diagnosed a week before his 18th birthday. He was death within 3 months. Five years (even one) would have meant the world to me and his family.

7

DigitalParacosm t1_ixwvubs wrote

So young. We usually see men in their mid 30s, but I remember hearing that if a patient is diagnosed younger than that: it can be very aggressive.

I’m so sorry to hear that he passed so quickly after diagnosis. Our patients usually had 10-12 months depending on how quickly their GBM was caught, and their immune response to treatment. Many patients had maybe 6 months to arrange and prepare for the patients death.. so I truly cannot imagine having only 90 days to prepare for the unpreparable.

5

bilyl t1_ixvsg0d wrote

A little? You’re understating it.

5