The Owl House covers a lot of stuff in this vein.

Luz mourns her dad, Eda deals with what can be compared to a chronic physical or mental illness, and there's a lot of stuff about complicated family dynamics that's handled with a lot of grace.

S2 also has the characters only very barely preventing a Puritan dictator from committing genocide.

It handles some pretty heady stuff very elegantly, so naturally Disney decided it's not their brand and cancelled it.