I've only lived in the area since late 2017 so take that as you will, but the only difference I've noticed was the closure of classic DC spots (18th st lounge, Marvin, etc). The nightlife doesn't feel as vibrant as it was pre-pandemic (but then again it's also winter time). But I never feel completely unsafe in DC. Just use your common sense and exercise any caution you would use in any major city.