Are you asking about the abstract I put in another comment? The authors labeled Tregs in the gut and saw them appear at the site of injuries; disabling them early (by a genetic knockout or antibiotics) impeded proper healing. You can draw your own dietary conclusions, whether that be eating healthy foods or probiotics; the paper just pointed to oral antibiotics as potentially hazardous.
Specific microbial signals induce the differentiation of a distinct pool of RORγ+ regulatory T (Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations of microbiota-dependent Treg cells that promoted tissue regeneration at extra-gut sites, notably acutely injured skeletal muscle and fatty liver. Inflammatory meditators elicited by tissue damage combined with MHC-class-II-dependent T cell activation to drive the accumulation of gut-derived RORγ+ Treg cells in injured muscle, wherein they regulated the dynamics and tenor of early inflammation and helped balance the proliferation vs. differentiation of local stem cells. Reining in IL-17A-producing T cells was a major mechanism underlying the rheostatic functions of RORγ+ Treg cells in compromised tissues. Our findings highlight the importance of gut-trained Treg cell emissaries in controlling the response to sterile injury of non-mucosal tissues.
Forgind1 OP t1_jcn387a wrote
Reply to comment by TequillaShotz in Regulatory T Cells Mediate Proper Healing in Damaged Distal Tissues by Forgind1
Are you asking about the abstract I put in another comment? The authors labeled Tregs in the gut and saw them appear at the site of injuries; disabling them early (by a genetic knockout or antibiotics) impeded proper healing. You can draw your own dietary conclusions, whether that be eating healthy foods or probiotics; the paper just pointed to oral antibiotics as potentially hazardous.