Gu1l7y5p4rk
Gu1l7y5p4rk t1_izz1m59 wrote
Reply to Aging is associated with a systemic length-associated transcriptome imbalance -- short genes are associated with aging. The results are found in different organisms and cell types, and the length association responds to anti-aging interventions. by David_Ojcius
>We recognize that our study holds a far-reaching implication on how RNA-seq studies are analyzed and interpreted. Technical biases in RNA-seq studies, which affect gene-specific readouts according to their length, have been reported widely, and several tools have been subsequently deployed to computationally counter the effects of this length association40,41,42,43.
>Jointly, these observations invite the unsupported hypotheses that during aging there may not be a single origin for the length-associated transcriptome imbalance and that the length-associated transcriptome imbalance in aging instead represents an intermediate step within a ‘bowtie structure’ through which multiple environmental and internal conditions simultaneously affect multiple downstream outputs55,56,57.
Above and below and between is much talk and mention of methods and incidents supporting the above quoted/mentioned.
Gu1l7y5p4rk t1_jb7aato wrote
Reply to What might slow this down? by Beautiful-Cancel6235
>We are all getting whiplash from the breakneck speed of AI development and adoption/integration.
I'm not, and I think your prone. ;)