KetosisMD
KetosisMD t1_jecg432 wrote
Reply to New research (N=70,190) shows higher pro-inflammatory diet increases the risk of depression in U.S. adults, by maxwell-cady
The new index, an empirical dietary inflammatory index (eDII), is based on 8 pro-inflammatory components (red meats, processed meats, organ meats, other fish, eggs, sugar-sweetened beverages, tomatoes, and refined grains) and 8 anti-inflammatory components (leafy green vegetables, dark yellow vegetables, fruit juice, oily fish, coffee, tea, wine, and beer or other alcohol beverages).
Not a fan of their definition of inflammatory.
Booze and juice ? Garbage
KetosisMD t1_je5zmbz wrote
Reply to comment by MethosofGondor in Ultramassive black hole over 30 billion times mass of our sun has been spotted. The discovery had been made possible thanks to a phenomenon known as gravitational lensing — the first time a black hole has been spotted in such a way. by Wagamaga
>But how many elephants is that?
It's alot of elephants as well !
Thanks for pointing this out !!
KetosisMD t1_je53298 wrote
KetosisMD t1_jdz1vtj wrote
Reply to The risk of developing osteoarthritis, a common, incurable form of the condition, was 58% higher among those with eczema or asthma compared to the general population. Those with both asthma and eczema were twice as likely to develop osteoarthritis compared to the general population. N = 100,000+ by MistWeaver80
> ⇒ This study demonstrates an association between atopic disease and the development of OA; patients may benefit from the use of treatments that inhibit mast cells and allergic cytokines to treat or prevent OA.
Ketotifen fumarate (Zaditen®; Swedish Orphan Biovitrum) functions as a mast cell stabiliser and has been used as a treatment for chronic idiopathic urticaria because of its antipruritic properties. Similarly, epinastine hydrochloride is both an antihistamine and a mast cell stabiliser.
Within the flavone class, the most active mast cell stabilizers are luteolin, disometin and apigenin. Using anti-IgE to elicit degranulation, luteolin inhibited the release of histamine, LTs, PG2 and GM-CSF from human cultured mast cells (HCMCs) in a concentration-dependent manner (1–100 μM) (Kimata et al., 2000b). Luteolin also suppressed the production of proinflammatory cytokines TNF-α and IL-6 in bone marrow-derived cultured murine mast cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764846/
Glucosamine stabilizes mast cells as well.
KetosisMD t1_jdmhtug wrote
Reply to Depressed, and Aging Fast. People with higher levels of aging-associated proteins were more likely to have high blood pressure, and multiple medical problems. The accelerated aging was also associated with worse performance on tests of brain health such as working memory and other cognitive skills. by Wagamaga
They used 22 protein levels to assess an aging index called SASP:
Here are the 22 proteins:
> As in our previous studies28,30, the 22 proteins included in the SASP index used in the present study are IGFBP-6, IGFBP-2, MIP-1β, IL-1β, GMC-SF, PLGF, Angiogenin, MIF-1, MIP-1α, Gro-α, IL-6, MCP-4, Gp130, ICAM-1, MCP-1, IL-8, MIP-3 α, Osteoprotegerin, TIMP-1, uPAR, TNFRI and TNFRII. The raw values were log transformed and standardized to z scores, and the SASP index for each participant was calculated
> Cellular senescence11 has emerged as a pivotal hallmark of the biology of ageing. It is a complex stress response in which cells irreversibly lose their proliferative capacity, become resistant to apoptosis12 and develop a multicomponent secretory phenotype13, referred to as the senescence-associated secretory phenotype (SASP)12. The SASP includes proteins involved in cycle control, intercellular communication, the immune-inflammatory response and tissue remodelling14. Under non-pathological conditions, SASP proteins are essential for embryonic development and tissue patterning throughout life15. However, the accumulation of senescent cells and the increased secretion of SASP proteins with age is linked to tissue deterioration and the emergence of physical disorders prevalent in older adults16. Human and animal studies found that the increased expression of SASP proteins drives multiple age-related phenotypes, such as atherosclerosis17, osteoarthritis18, cancer19, kidney dysfunction20 and a shortened health span21. In humans, an increase in SASP proteins is related to obesity, cardiometabolic dysregulation22 and frailty14. Several studies characterized the role of cellular senescence and SASP proteins in the brain. Aged microglia, astrocytes and neurons exhibit various features of senescence, including the expression of SASP proteins23,24,25.
> While the cellular source of SASP proteins is unknown, some evidence suggests that the SASP index is relevant to brain health and that brain cells express SASP proteins23,24,25. In ageing and psychiatric disorders, the blood–brain barrier permeability is increased71, leading to an enhanced passage of proteins. Some studies suggest that plasma from old mice accelerates brain ageing in young mice72, and senolytic interventions targeting the periphery alleviate the effect of SASP proteins on the brain71.
Unknown !
Blood brain barrier permeability increased.
KetosisMD t1_jc2ypcx wrote
Reply to comment by Meatrition in Optimal dietary patterns for prevention of chronic disease: Participants with low insulinemic , low inflammatory or diabetes risk-reducing diet had the largest risk reduction for incident major CVD, type 2 diabetes and cancer as a composite and individually by Meatrition
> can’t find full text
Your institution doesn’t have a subscription ?
KetosisMD t1_jbnq1cx wrote
Reply to comment by That-Group-7347 in Comprehensive review and trial results of upcoming antidepressant Ruoxinlin (ansofaxine) by That-Group-7347
Nefazodone ..
Haven’t heard that drug name in years !
https://en.m.wikipedia.org/wiki/Nefazodone
Withdrawn due to toxicity
KetosisMD t1_jbgcq8d wrote
Reply to Impact of a Low-Insulin-Stimulating Bread on Weight Development—A Real Life Randomised Controlled Trial — rye bread from milled whole grain (control) or a medium-carbohydrate, low-insulin-stimulating bread (intervention). Significant weight reduction was observed in the intervention group. by Meatrition
People lost 4 lbs in 3 months eating the low carb bread. People over 55 lost 5 lbs.
> The rye bread was made from type 997 flour, the low-insulin-stimulating bread consisted of oat flakes, sunflower seeds, flax seeds, chia seeds, psyllium husks, chopped almonds, baker’s honey, and Rhinish field beans
KetosisMD t1_j95w9me wrote
Reply to comment by Sculptasquad in Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression (Feb 2023) by basmwklz
Agreed. I’m not saying rapamycin is safe. I’m tempering the comparison of C and rapamycin
KetosisMD t1_j95rx8w wrote
Reply to comment by crazyhadron in Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression (Feb 2023) by basmwklz
Probably not as thorough as rapamycin.
KetosisMD t1_j8yri7b wrote
Reply to Paxlovid slashed severe outcomes for at-risk patients after Omicron surge, study finds by No-Drawing-6975
> unvaccinated only
Key feature
KetosisMD t1_j842xki wrote
Reply to Non-processed meat-based diet during puppyhood may protect dogs against certain digestive disorders later in life while kibble is a potential risk factors. by neline_the_lioness
> dog kibble (ultra processed junk food) is bad for dog health
Ya don’t say.
Not a surprise.
> dog eating table scraps was good
Better than kibble.
KetosisMD t1_j7lcj13 wrote
Reply to comment by ---LJY--- in Tilavonemab in early Alzheimer’s disease: results from a phase 2, randomized, double-blind study by burtzev
Absolutely zero.
it’s all prevention:
Everything that’s good for the heart is good for the brain.
KetosisMD t1_j7iwutt wrote
Reply to comment by buzmeg in Analysis showed that 65.6% of women who took extra Vitamin D gave birth naturally. The study analysed results from the MAVIDOS trial which involved 965 women being randomly allocated an extra 1,000 International Units (IU) per day of vitamin D during their pregnancy or a placebo. by Wagamaga
Too much D lowers folic acid.
This paper says sun (ultraviolet rays) exposure Lowers folate not vitamin D
> Vitamin D and folate are two unrelated nutrients with disparate sensitivities to UVR; vitamin D is synthesised and folate is degraded in the skin following UVR exposure.
KetosisMD t1_j7im6t0 wrote
Reply to comment by Xinlitik in Tilavonemab in early Alzheimer’s disease: results from a phase 2, randomized, double-blind study by burtzev
You’d think !
The trials will fail. All these new Alzheimer’s drugs are garbage.
KetosisMD t1_j7i14jt wrote
Reply to comment by burtzev in Tilavonemab in early Alzheimer’s disease: results from a phase 2, randomized, double-blind study by burtzev
That’s nuts.
I can’t believe anyone prescribed dangerous placebos.
It’s hard to know what is more broken the FDA or Healthcare
Edit
> 1.5 million treated
No, 1.5 million would be eligible. CMS denied coverage to anyone who isn’t in a trial.
This is good news. I was hoping CMS would pass on this drug and they did.
KetosisMD t1_j7hs2pf wrote
Reply to comment by burtzev in Tilavonemab in early Alzheimer’s disease: results from a phase 2, randomized, double-blind study by burtzev
Zero surprise.
KetosisMD t1_j7hl1h6 wrote
Reply to Analysis showed that 65.6% of women who took extra Vitamin D gave birth naturally. The study analysed results from the MAVIDOS trial which involved 965 women being randomly allocated an extra 1,000 International Units (IU) per day of vitamin D during their pregnancy or a placebo. by Wagamaga
> 1000 IU
Yet in 2011, it was shown that pregnant women need 4000 IU daily.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183324/
Yet another case of vitamin D under dosing and it still worked.
KetosisMD t1_j6mj0wh wrote
Reply to comment by [deleted] in Researchers develop coating that prevents synthetic fabrics from shedding harmful microplastics in the wash by BlitzOrion
And that it’s a forever chemical
KetosisMD t1_j5wutqe wrote
Reply to comment by cshaiku in Insulin-regulated serine and lipid metabolism drive peripheral neuropathy by dissolutewastrel
Type 2 Diabetes (over 95% of diabetes) is easily reversible with a proper low carb diet.
KetosisMD t1_j5vloto wrote
Reply to A new study has linked nitrates in processed meat to an increased risk of type 2 diabetes by BlitzOrion
Nutritional epidemiology is a total and complete failure.
This is just another stupid example.
LINKED means Jack ****.
KetosisMD t1_j4bcwrp wrote
ApoE4 is five letters and should have been in the title.
KetosisMD t1_j49fysl wrote
Reply to comment by Cleistheknees in A systematic review and meta-analysis shows that the consumption of sugar-sweetened beverages was positively associated with an increased risk of metabolic syndrome. by glawgii
Love your post. Knowledge is power.
Thoughts on this ?
https://www.crossfit.com/essentials/insulin-is-not-required-for-glucose-uptake-into-cells
> get glucose intake to match glucose-independent uptake
If blood glucose was stable and it went up 18mg/dl (1 mmol) wouldn’t that indicate the intake was too high ?
KetosisMD t1_j3qy8k1 wrote
Reply to Reformulating packaged foods available in Australia to contain less sodium may save about 1,700 lives per year & may also prevent nearly 7,000 annual diagnoses of heart disease, kidney disease and stomach cancer. by MistWeaver80
> salt
The evil white powder is sugar.
Sugar spikes insulin and causes salt retention.
No sugar = just pee out the salt.
Nothing wrong with lowering salt intake, but the killer white powder is sugar.
Final answer.
> reformulate packaged food.
ahem, eliminate.
You know something is bad for you if it has a nutrition label
Processed food is just sugar, salt, low quality oil and wheat. Lowering salt in fake food isn’t going to do much.
KetosisMD t1_jecsayd wrote
Reply to comment by Maltese_Vulcan in New research (N=70,190) shows higher pro-inflammatory diet increases the risk of depression in U.S. adults, by maxwell-cady
It’s not possible. Juice sales are falling for good reason. Apple = good, apple juice = processed junk food