Allergies are one of the leading causes of sinus infections (which are typically caused by viruses). That suggests that inflammation will not impede, but rather precipitate the infectivity of SARS-CoV-2.
Following infection, a systemic immune response is mounted, characterized by increased serum concentrations of chemokines and pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor (TNF), and the appearance of activated monocytes, followed by SARS-CoV-2-specific immunoglobulin M (IgM), IgA, and IgG antibodies and interferon-γ-producing T cells. This concerted action of the immune system controls the replication of SARS-CoV-2.
With that said, the question is whether or not the preexisting inflammation would also result in the immune system detecting the virus earlier than it would in subjects without active allergies. It does seem likely that patients with already elevated levels of immunoglobulin would help detect the virus sooner and would likely result in better outcomes (i.e. no PACs 'long covid).
/u/Anthrogal11 my hypothesis is that you would have a higher rate of infection but also be more likely to present as asymptomatic. Something that may confound the above is if your allergies are so bad that they significantly restrict airflow through your sinuses.
MoreTrueStories t1_is85li9 wrote
Reply to comment by ZSpectre in SARS-CoV2 enters the brain through the olfactory nerve in rhesus monkeys, causing neuroinflammation. The virus spread further into the brain in aging animals. by andyhfell
Allergies are one of the leading causes of sinus infections (which are typically caused by viruses). That suggests that inflammation will not impede, but rather precipitate the infectivity of SARS-CoV-2.
Following infection, a systemic immune response is mounted, characterized by increased serum concentrations of chemokines and pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor (TNF), and the appearance of activated monocytes, followed by SARS-CoV-2-specific immunoglobulin M (IgM), IgA, and IgG antibodies and interferon-γ-producing T cells. This concerted action of the immune system controls the replication of SARS-CoV-2.
With that said, the question is whether or not the preexisting inflammation would also result in the immune system detecting the virus earlier than it would in subjects without active allergies. It does seem likely that patients with already elevated levels of immunoglobulin would help detect the virus sooner and would likely result in better outcomes (i.e. no PACs 'long covid).
/u/Anthrogal11 my hypothesis is that you would have a higher rate of infection but also be more likely to present as asymptomatic. Something that may confound the above is if your allergies are so bad that they significantly restrict airflow through your sinuses.