Space is full of valuable resources. One asteroid could have a particular rare mineral x10 of that of earth. No doubt in my mind that the space economy will transition from science to manufacturing once certain thresholds are met. Not anytime soon, but perhaps within our lifetime.

I'd imagine AIs would do all the management on-site. Repairs would be done by maintenence drones and bots. All humans need to do is send annual production quota and finished products are sent to earth orbit to be picked up. We're not talking near-near future here though. In maybe 80 years?

Off world manufacturing would probably be 100% automated, no people involved

Future organic wife? Who are you kidding!