PresidentialCamacho
PresidentialCamacho t1_ix5f8n8 wrote
Reply to Do NSAIDs reduce neuroinflammation? by One-Garden-1294
Conclusion: Free ibuprofen, flurbiprofen, and indomethacin rapidly cross the BBB, with ibuprofen exhibiting a saturable component of transport. Plasma protein binding limits brain NSAID uptake by reducing the free fraction of NSAID in the circulation. https://link.springer.com/article/10.1007/s11095-006-9905-5
The article says in the real world NSAIDs, free ibuprofen, are bounded to plasma which limits the concentration that can actually cross the BBB.
PresidentialCamacho t1_j1gq6qv wrote
Reply to Congress passes the FDA Modernization Act removing the animal testing requirement and allowing developers to use human-relevant tech. like organ chips in drug development by darkened-foxes
Morons. This bill is meant to allow BPs to cut corners and lead to human misery and deaths. Testing on multiple mammalian species reduces the chance that we provide a novel drug that messes up children for life. There's nothing to be happy about. There's nothing trivial about testing drugs in systemic environments. No amount of modeling and small tests beats the complex microenvironment of animals. We only know <1% of the body. Anyone claiming more is a liar.