jangiri

jangiri t1_ir6di2d wrote

Reply to The Nobel Prize in Chemistry 2022: Awarded jointly to Carolyn R. Bertozzi, Morten Meldal, and K. Barry Sharpless "for the development of click chemistry and bioorthogonal chemistry" by shiruken

I will say I do love the format of this Nobel award, really giving it to a vertical slice of chemistry, from the synthetic chemists who came up with the techniques, to Bertozzi who is just brilliant in the way she constructs experiments to understand biology. It makes the point that often the best chemistry is tremendously collaborative and adjacent fields can skyrocket each other with even modest interaction. I'm having trouble finding ways how people can make themselves mad about this award, it seems incredibly well deserved.

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jangiri t1_ir6cy2q wrote

Reply to comment by [deleted] in The Nobel Prize in Chemistry 2022: Awarded jointly to Carolyn R. Bertozzi, Morten Meldal, and K. Barry Sharpless "for the development of click chemistry and bioorthogonal chemistry" by shiruken

I've heard the story of how Sharpless came up with the Click reaction and it was basically him listing a bunch of qualities in a reaction that would fill this need in biology. Him and his lab then just searched for it and they found the click reaction and then it blew up. It's the combo of knowing what biology research required, and the organic chemistry that could make that happen which really makes this such an elegant development.

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