jayboknows
jayboknows t1_j80hz8h wrote
Reply to comment by MushroomNovaCat in Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (Feb 2023) by basmwklz
Diet composition compared to energy intake has also been investigated in animals. Read the introduction to the linked study and the authors discuss previous findings demonstrating CR working independently from diet composition.
“We recently completed a longitudinal study in male C57BL/6J mice (B6) initiated at 4 months of age in which the effects of the two diet compositions under ad libitum (AL) and CR conditions were measured (Mitchell et al., 2019). Independent of diet, male B6 mice on 30% CR exhibited significant improvements in health, survival, and a delayed onset of cancer with respect to AL-fed mice.”
https://www.sciencedirect.com/science/article/pii/S1550413120302357
jayboknows t1_j7zngdw wrote
Reply to comment by MushroomNovaCat in Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (Feb 2023) by basmwklz
​
As the authors noted, this can be seen in multiple species. In animal trials, caloric intake is often achieved by manipulating quantity of food, not type. This could suggest that energy would independently impact longevity, and that it's not simply a matter of eliminating highly processed foods. While animal studies are not the highest degree of evidence, they are often useful for determining mechanisms of action when confounding variables like this can be accounted for. This is not to say that diet quality does not also have an independent or synergistic effect on longevity, but it would point toward energy intake being a piece of the puzzle, at least.
jayboknows t1_j484ju0 wrote
Reply to comment by Sanpaku in A systematic review and meta-analysis shows that the consumption of sugar-sweetened beverages was positively associated with an increased risk of metabolic syndrome. by glawgii
Thank you for the in-depth response
jayboknows t1_j81dmi6 wrote
Reply to comment by MushroomNovaCat in Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (Feb 2023) by basmwklz
I do not dispute that fiber has health promoting benefits. I do feel that it’s a bit of a straw man from the original point, though. The discussion seemed to be that the less processed food, in the blue zones, was responsible for increases in longevity, independent from CI. From that perspective, I believe the animal studies, where diet composition is the same (degree of processing isn’t different) and CI is the IV, are useful. I believe they provide evidence that energy intake affects longevity independent processed food consumption.