king5327

king5327 t1_jdyslcs wrote

Healthy and cancerous cells have almost exactly the same DNA. Minus a few mutations. CRISPR can target them, but might not necessarily be able to do anything useful at those locations.

CRISPR can't tell the difference between cells, it only targets specific sequences. Cancer can be caused by many different mutations, some of which won't cause it on its own. A bad target could lead to complications.

CRISPR has to work on all of the cells, otherwise the stragglers will start a new tumor.

Altogether, for CRISPR to work needs a safe target where the change will be effective and it has to wipe the floor with all of the cancer. Which means the patient needs to be lucky for it to even be a possibility, even if the success rate is high once administered.

(Source: mostly things I've read over the past decade and a half, I may be out of date)

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king5327 t1_j8g3a59 wrote

A tunnel is a terrible place to have a train, on account of needing enough space around it to pass the air, else you enjoy a pressure bubble at the front of the train. But increasing the cross section of a vacuum tube is a non-negligible nerf to the effectiveness of the vacuum pumps, causing similar drag anyway.

This leads me to believe that even if the technology works perfectly, the numbers alone won't allow for the performance that was promised, unless at extraordinary expense in running the pumps.

Edit: Also, if there are any magnets at all on the car, or along the length of the tunnel, induction is going to be a surprise drag.

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king5327 t1_ixj4r3h wrote

At some intersections, cars will stack twenty back on all lanes before the light gives them right of way. The logistics of moving them aside would take longer than just waiting for it to change.

This proposal is to add systems which change the light when an emergency vehicle approaches, so the issue never had to come up in the first place.

Edit: Also there needs to be space to the side to move the car. Doesn't matter how much space you leave in front for turning if all ways are obstructed.

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king5327 t1_itidb6h wrote

I haven't read the proposal yet but it sounds like it would just become A Modest Proposal once we fix the value of a child's life to the amount of people its flesh would feed.

Edit: Or worse, the highest bid a cannibalistic gourmet would pay. The higher the price, the less appealing the number of children saved/sacrificed would be, since the high value would lower the number.

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