Probably nothing beyond a bit of refocusing with what goes where, Cartoons have been getting cancelled since they've been on TV. Today's Pantheon and Infinity Train is last decade's Generator Rex and Symbionic Titan. Good shows will sometimes get their run, good shows may sometimes not.

Edit: I always feel like people forget this, but Gravity Falls was created with just two seasons in mind specifically because of how often cartoons were cancelled. It was just way less noticeable when shows were episodic so they'd simply just end and the creator wasn't on twitter to talk about not getting renewed.

The writers on this show are just on that good shit man. Nemik, Luthen and Marva's speeches are so layered, they're great in a vacuum but what makes them so good is the effort they put into the world to make it hit.