Solid organs contain macrophages, specialized to each organ. When a solid organ is first transplanted, the macrophages have the same DNA as the donor, but over time they can be replaced from the bone marrow of the recipient. It's not as simple as a constant stream of macrophages coming from the bone marrow, though. The "resident macrophages" can be produced from within the organ, from their own population of stem cells. But if something happens and the population of these cells within the organ is depleted, new cells can come in from the bone marrow of the recipient and therefore would have the DNA of the recipient.
This process of movement of macrophages can also go the other way. Some people who have received a transplanted organ end up with donor macrophages in places like skin and lymph nodes.
The number of cells that are moving around like this is fairly small. The large majority of the cells of the organ aren't replaced from outside of the organ and therefore keep the original DNA of the donor.
rachaeltalcott t1_ivsu7rp wrote
Reply to Does the dna of transplanted organs (organic material) change after the recipient successfully recovers? by theZoid42
Solid organs contain macrophages, specialized to each organ. When a solid organ is first transplanted, the macrophages have the same DNA as the donor, but over time they can be replaced from the bone marrow of the recipient. It's not as simple as a constant stream of macrophages coming from the bone marrow, though. The "resident macrophages" can be produced from within the organ, from their own population of stem cells. But if something happens and the population of these cells within the organ is depleted, new cells can come in from the bone marrow of the recipient and therefore would have the DNA of the recipient.
This process of movement of macrophages can also go the other way. Some people who have received a transplanted organ end up with donor macrophages in places like skin and lymph nodes.
The number of cells that are moving around like this is fairly small. The large majority of the cells of the organ aren't replaced from outside of the organ and therefore keep the original DNA of the donor.