rjmsci

rjmsci OP t1_j8tpods wrote on February 16, 2023 at 9:49 PM

Reply to comment by bannedPosts in Psychedelics activate the same receptors as serotonin, so why aren't we always tripping? Psychedelics may cause neuronal plasticity and relieve depression by activating intracellular serotonin receptors that serotonin itself cannot, suggests a new study. by rjmsci

I think quoting the Moncrieff paper is a mistake here - that's an article with an agenda. Depression is not caused by lowered serotonin activity, sure, but compounds that primarily modulate the serotonin system do relieve it. It's up to the field to unravel the mechanisms behind this. Do these intracellular 5ht2as kick off pathways that surface receptors don't? How do different serotonin agonists affect these receptors? This is exactly the kind of research the field needs to answer these questions.

rjmsci OP t1_j7py4pq wrote on February 8, 2023 at 4:09 PM

Reply to A new study has explored changes to the gut microbiome in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The study identified that people who were diagnosed with the condition less than four years previously have altered proportions of certain microbiota species. by rjmsci

Couldn't fit it in the title, but an interesting factor is that long-term ME/CFS patients had microbiota that looked like that of health controls. But instead they had metabolic alterations in their plasma - suggesting that changes in the microbiota may lead to long-term changes elsewhere. Also, correlation not causation, folks!

Link here: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00021-5

rjmsci OP t1_itzyvt0 wrote on October 27, 2022 at 3:20 PM

Reply to Researchers have shown that individuals who are played a piano chord during sleep that was previously paired to a specialist form of nightmare therapy have happier dreams and fewer nightmares than those who didn't undergo previous pairing, showing that this approach can alter emotions in dreams. by rjmsci

Original paper here: https://www.cell.com/current-biology/fulltext/S0960-9822(22)01477-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982222014774%3Fshowall%3Dtrue

rjmsci OP t1_isycf5q wrote on October 19, 2022 at 4:26 PM

Reply to comment by Hike_it_Out52 in Natural Selection Driven by the Black Death Linked to Modern-Day Autoimmune Disease: Analysis of DNA from over 200 remains shows that the Black Death selected for immune gene variants that are also risk factors for autoimmune conditions like Crohn's disease. by rjmsci

Thanks!

rjmsci OP t1_isyb6bu wrote on October 19, 2022 at 4:18 PM

Reply to Natural Selection Driven by the Black Death Linked to Modern-Day Autoimmune Disease: Analysis of DNA from over 200 remains shows that the Black Death selected for immune gene variants that are also risk factors for autoimmune conditions like Crohn's disease. by rjmsci

Sixth-grader explanation: We all have different types of genes, called alleles. Some alleles can be useful in certain situations. In medieval Eurasia, it seems that having some alleles helped people not die of the Black Death. That means that after the Black Death, those alleles became more common. However, nowadays, those more common alleles are now unhelpful as they may increase the risk of getting autoimmune conditions. Hope that helps!

rjmsci OP t1_isy2i0z wrote on October 19, 2022 at 3:21 PM

Here's the original study: https://www.nature.com/articles/s41586-022-05349-x

rjmsci

rjmsci OP t1_j8tpods wrote on February 16, 2023 at 9:49 PM

Psychedelics activate the same receptors as serotonin, so why aren't we always tripping? Psychedelics may cause neuronal plasticity and relieve depression by activating intracellular serotonin receptors that serotonin itself cannot, suggests a new study.

rjmsci OP t1_j7py4pq wrote on February 8, 2023 at 4:09 PM

A new study has explored changes to the gut microbiome in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The study identified that people who were diagnosed with the condition less than four years previously have altered proportions of certain microbiota species.

A new study has found that a gene variant that causes a flush reaction after alcohol consumption also increases inflammation and impacts circulation. This finding could explain why individuals carrying this gene variant also have an increased risk of developing a common type of heart disease.

Researchers have developed a liquid metal robot that can shapeshift. In its solid form, the robot's gallium body can withstand 30 times its own weight, but it can flow fluidly in a liquid form. Scientists believe it could be used to solve engineering challenges or even deliver drugs inside the body.

Nine Paralysis Patients Walk Again; Neuronal Population Required for Recovery Identified: A new study has identified nerve cells that are altered in response to a spinal cord stimulation technique proven to restore walking ability in people once thought to be permanently paralyzed.

rjmsci OP t1_itzyvt0 wrote on October 27, 2022 at 3:20 PM

Researchers have shown that individuals who are played a piano chord during sleep that was previously paired to a specialist form of nightmare therapy have happier dreams and fewer nightmares than those who didn't undergo previous pairing, showing that this approach can alter emotions in dreams.

rjmsci OP t1_isycf5q wrote on October 19, 2022 at 4:26 PM

rjmsci OP t1_isyb6bu wrote on October 19, 2022 at 4:18 PM

rjmsci OP t1_isy2i0z wrote on October 19, 2022 at 3:21 PM

Natural Selection Driven by the Black Death Linked to Modern-Day Autoimmune Disease: Analysis of DNA from over 200 remains shows that the Black Death selected for immune gene variants that are also risk factors for autoimmune conditions like Crohn's disease.