shiny_brine
shiny_brine t1_j95vmua wrote
Reply to comment by AllanfromWales1 in Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression (Feb 2023) by basmwklz
The difference is delivery. Pharmacological is delivered in a manner that bypasses natural VC regulation and can achieve much higher concentrations.
shiny_brine t1_j95vewl wrote
Reply to comment by crazyhadron in Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression (Feb 2023) by basmwklz
It's the delivery that's different. This is intravenous and bypasses natural regulation, thus providing concentrations not easily obtained otherwise.
shiny_brine t1_iwsyy7z wrote
Reply to Earth’s oldest evidence of life – Australian fossils dating to about 3.48 billion years ago – could provide hints of what scientists should look for on Mars by marketrent
So you're saying this life originated in a "shiny brine"?
shiny_brine t1_j967hy2 wrote
Reply to comment by AllanfromWales1 in Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression (Feb 2023) by basmwklz
To simplify a very complex system, there are four main uptake paths for VC (passive diffusion, facilitated diffusion, active transport and recycling through the kidneys). Difference subsystems (brain, lungs, heart, muscles etc.) can each tolerate different levels of vitamin C and regulate levels through the use of different uptake paths. These levels are lower than the levels discussed in the paper obtained through intravenous means. If the body were exposed to long term high levels as discussed in the paper, there would be concerns of damage to many of the systems that need to regulate much lower levels. If one where to ingest large doses it would mostly go through the recycle system and be removed by the kidneys before it would get to the sub-systems.