https://www.mcsweeneys.net/articles/yinzerotica-erotica-for-pittsburghers

At his best, Nietzsche was very witty and could write a hell of an aphorism. At his worst he was angry and lashed out at the world in grandiose and pathetic ways.

His discussions of atheism and morality are normally pretty half-baked and without depth. The area he seems to have cared the most about, and where he is at his best (in my opinion) is his conception of the Eternal Recurrence of the Same. That's not unique to him but he alone really develops that idea in ways that no other contemporary existentialists do. It's worth wading through some of his otherwise syphilis-addled edgelordism to read these parts of his works of you have the time and stomach for it.

There's also a shift in thyroid hormone levels with a similar result, as well as competition for binding sites with other NHRs such as RAR and RXR.

Additionally, many of these are upstream of other transcription factors either directly or via classic signaling pathways, so there's a whole range of ways in which puberty acts on gene transcription!