Not_as_witty_as_u t1_irfzbwc wrote on October 7, 2022 at 8:19 PM

Reply to comment by Glodraph in A bold effort to cure HIV—using Crispr by Sariel007

>2 main variants HIV-1 and HIV-2

Do they differ with symptoms, treatment etc? Like is one more aggressive for example?

Glodraph t1_irg1pqk wrote on October 7, 2022 at 8:37 PM

I don't really know tbh, never actually studied a lot of viruses in detail, I only know the general mechanism of the HIV one but I don't really know anything as far as clinical data goes.

heytheremicah t1_irgr652 wrote on October 8, 2022 at 12:17 AM

Did a research project on HIV for a genetics course in undergrad. From what I remember, HIV-2 generally has a lower mortality rate than HIV-1 and is endemic in regions of West Africa. Both usually require a combination of drugs (2-3) as usually using only one will lead to drug resistance and these drugs are any combination of integrase inhibitors, non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors, NRTIs, etc. Usually there’s a genetic predisposition to acquiring drug resistance in HIV, so genetic screening is done beforehand to best determine which medications to prescribe.