Did a research project on HIV for a genetics course in undergrad. From what I remember, HIV-2 generally has a lower mortality rate than HIV-1 and is endemic in regions of West Africa. Both usually require a combination of drugs (2-3) as usually using only one will lead to drug resistance and these drugs are any combination of integrase inhibitors, non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors, NRTIs, etc. Usually there’s a genetic predisposition to acquiring drug resistance in HIV, so genetic screening is done beforehand to best determine which medications to prescribe.