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frequenttimetraveler t1_j3q3pkw wrote

Paper is pretty short and straightforward. They 'simply' delivered Yamanaka factors using an adenovirus vector, and the animals extended their REMAINING lifespan by 109% , which is a 6% increase in their overall lifespan. There s not a lot of discussion of cancers etc so let's wait until this passes peer review.

Oh, the wonders of science if you are a mouse

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Mokebe890 t1_j3qfkuq wrote

Yes but dont underestimate such thing. The point is to show that age reversal is possible and feasible in mammals. If you can show that it works then it basically changes the fact how we look at aging and disease, the point of change in thinking.

Just imagine what will happen when people will finally know that aging is reversable. Then we can work to prevent teratomas, cancer and other downsides of it along the way.

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frequenttimetraveler t1_j3qfydy wrote

yes i didn't mean to. they DOUBLED their remaining life. Would be ideal if they doubled overall life exp. And we don't know what would happened if they intervened earlier

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Mokebe890 t1_j3qiips wrote

Excatly, just one step at time, remaining life, early life, overall life, its matter of changing the public opinion.

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civilrunner t1_j3xioul wrote

Would be curious if whatever their cause of death received the same reprogramming or not. Simply removing one cause of age related death doesn't prolong life long since something else is normally close behind, you have to nearly do a full body reprogram which is far harder.

It will be interesting to learn more about the study.

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LightbulbMaster42 t1_j3qgt8g wrote

Imagine tyrants living to 300 years old. Sounds like a great idea /s

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KnightOfNothing t1_j3qhulu wrote

see there's a simple solution to that problem, it's this really cool trick for getting rid of tyrants and get this it's been around since forever but modern people seem to have completely forgotten about it

eliminating aging does not eliminate other sources of death, just the most certain one.

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Mokebe890 t1_j3qif97 wrote

Uff good thing you put that s on the end

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Blackmail30000 t1_j3ty43y wrote

Imagine having a hundred years to concoct a assassination plot.

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QwertzOne t1_j3r6v84 wrote

I wonder, if advances in quantum biology could provide some answers for solving cancer and aging: A quantum theory of disease, including cancer and aging .

I learned lately that quantum physics explains how a tadpole is able to turn into a frog, thanks to quantum tunneling.

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Mokebe890 t1_j3r8er7 wrote

Both artificial general intelligence and quantum theories are wonderful but honestly I prefer to take them with dose of scepticism. We sure should research them but first turning to more classical explanation of aging, cancer and disease would be more practical and short term feasable.

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iNstein t1_j3qiy7l wrote

Average or maximum lifespan. Very important difference. Average lifespan increase is generally very easy to achieve. 9% increase is not impressive. I want this sort of thing to work but we need to stick to the science and what really works.

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frequenttimetraveler t1_j3qopp6 wrote

Its 109% increase of the remaining lifespan. 6% life extension, but the intervention was in very old mice

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Ghoullum t1_j3q6di3 wrote

Wow, a 9% extension is nothing! We need something much more meaningful.

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Phoenix5869 t1_j3qwj2e wrote

This would translate to an extra 7.2 years (assuming the average lifespan is 80) if it worked in humans, which is something

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Ghoullum t1_j3vcyr6 wrote

Wow, so many negative votes. Imagine that you go to the Altos investors (the most funded start up ever) and you tell them that their most promising technology will give them a 6% increase in longevity. They will be angry for sure haha. Caloric restriction has achieved in some cases up to 50% in some mammals... Rapa 20%. Acarbose close to 20%... IF 6% is the maximum we are going to get it is a big failure. I'm sorry all who are offended.

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WaitformeBumblebee t1_j3qd9tx wrote

if this is something that works by injecting again (not saying it is), then it's exactly what pharma companies want, life extension by subscription. Don't get behind your payments.

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Taron221 t1_j3qs71d wrote

>if this is something that works by injecting again (not saying it is), then it's exactly what pharma companies want, life extension by subscription.

If we aren't aging, then that just means they'll have to listen to us complain about the subscription over and over and over and over again. We'd have all the time in the world, lol.

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WaitformeBumblebee t1_j3r1fx1 wrote

Didn't you read the terms of service? Any complaint may result in immediate cancellation without recourse.

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Taron221 t1_j3r3edr wrote

Hmm, then every century we’ll draw straws or take new batches of world weary volunteers whose sole responsibility it will be to find new and creative ways to bully the Pharma CEOs. We’ll wear ‘em down eventually… That or we could just incessantly annoy politicians until it works, lol.

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ChickenTeriyakiBoy1 OP t1_j3prtg2 wrote

>A small biotech company claims it has used a technology called reprogramming to rejuvenate old mice and extend their lives, a result suggesting that one day older people could have their biological clocks turned back with an injection—literally becoming younger.

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Taron221 t1_j3qiuiz wrote

r/CureDeath is a sub centered on the topic of curing age-related death if that interests anyone. It mostly aggregates articles but also has the occasional discussion on the ramifications and nuisances of a future without aging.

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Black_RL t1_j3sm2dw wrote

Fix the code, fix the problem!

We’re just energy organized by code, once we dominate that, most problems should be gone.

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moist_yoda t1_j3rhp4n wrote

So when can we buy genetically engineered rats that live up to 12 years? Pet rats live too short which sucks Because their such amazing animal.

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UniversalMomentum t1_j3rtdma wrote

What happens when they get into the wild and breed like normal rats but live 4 times longer?

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moist_yoda t1_j3rud3u wrote

Probably get killed by all the feral cats where I live.

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myusernamehere1 t1_j3shj7n wrote

I doubt the gene alterations are heritable, unless they affect germ line cells

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FuturologyBot t1_j3pupcl wrote

The following submission statement was provided by /u/ChickenTeriyakiBoy1:

>A small biotech company claims it has used a technology called reprogramming to rejuvenate old mice and extend their lives, a result suggesting that one day older people could have their biological clocks turned back with an injection—literally becoming younger.

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/1081uhw/this_biotech_startup_says_mice_live_longer_after/j3prtg2/

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AndromedaAnimated t1_j3r4g43 wrote

It’s very interesting! A question though. Don’t they use the „black 6“ strain mice for that usually? Since they are already relatively long-lived (of my 6 lab pensioner „black 6“ mice, 4 are still alive and kicking after 2 years). They have black fur, not white/albino 😁

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VTX002 t1_j3som95 wrote

That remind me of something in a sci-fi book it called Prolong. And if anybody interested in what book is called honor Harrington series from the writer David Weber.

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LightbulbMaster42 t1_j3qgosm wrote

The absolute last thing we need is privileged wealthy fucks living longer

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Terowrath t1_j3shd8y wrote

Idk why you're getting downvoted, technology like this would 100% be exploited by the rich

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