Submitted by ChickenTeriyakiBoy1 t3_1081uhw in Futurology
Comments
[deleted] t1_j3ptibb wrote
[removed]
FuturologyBot t1_j3pupcl wrote
The following submission statement was provided by /u/ChickenTeriyakiBoy1:
>A small biotech company claims it has used a technology called reprogramming to rejuvenate old mice and extend their lives, a result suggesting that one day older people could have their biological clocks turned back with an injection—literally becoming younger.
Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/1081uhw/this_biotech_startup_says_mice_live_longer_after/j3prtg2/
frequenttimetraveler t1_j3q3pkw wrote
Paper is pretty short and straightforward. They 'simply' delivered Yamanaka factors using an adenovirus vector, and the animals extended their REMAINING lifespan by 109% , which is a 6% increase in their overall lifespan. There s not a lot of discussion of cancers etc so let's wait until this passes peer review.
Oh, the wonders of science if you are a mouse
Ghoullum t1_j3q6di3 wrote
Wow, a 9% extension is nothing! We need something much more meaningful.
WaitformeBumblebee t1_j3qd9tx wrote
if this is something that works by injecting again (not saying it is), then it's exactly what pharma companies want, life extension by subscription. Don't get behind your payments.
Mokebe890 t1_j3qfkuq wrote
Yes but dont underestimate such thing. The point is to show that age reversal is possible and feasible in mammals. If you can show that it works then it basically changes the fact how we look at aging and disease, the point of change in thinking.
Just imagine what will happen when people will finally know that aging is reversable. Then we can work to prevent teratomas, cancer and other downsides of it along the way.
frequenttimetraveler t1_j3qfydy wrote
yes i didn't mean to. they DOUBLED their remaining life. Would be ideal if they doubled overall life exp. And we don't know what would happened if they intervened earlier
LightbulbMaster42 t1_j3qgosm wrote
The absolute last thing we need is privileged wealthy fucks living longer
LightbulbMaster42 t1_j3qgt8g wrote
Imagine tyrants living to 300 years old. Sounds like a great idea /s
KnightOfNothing t1_j3qhulu wrote
see there's a simple solution to that problem, it's this really cool trick for getting rid of tyrants and get this it's been around since forever but modern people seem to have completely forgotten about it
eliminating aging does not eliminate other sources of death, just the most certain one.
frequenttimetraveler t1_j3qi3pl wrote
In rome they just killed the emperors
frequenttimetraveler t1_j3qi80n wrote
We start with a high rise window
Mokebe890 t1_j3qif97 wrote
Uff good thing you put that s on the end
Mokebe890 t1_j3qiips wrote
Excatly, just one step at time, remaining life, early life, overall life, its matter of changing the public opinion.
Taron221 t1_j3qiuiz wrote
r/CureDeath is a sub centered on the topic of curing age-related death if that interests anyone. It mostly aggregates articles but also has the occasional discussion on the ramifications and nuisances of a future without aging.
iNstein t1_j3qiy7l wrote
Average or maximum lifespan. Very important difference. Average lifespan increase is generally very easy to achieve. 9% increase is not impressive. I want this sort of thing to work but we need to stick to the science and what really works.
datfixinboy t1_j3qmxzj wrote
They're not immune to being killed.
frequenttimetraveler t1_j3qopp6 wrote
Its 109% increase of the remaining lifespan. 6% life extension, but the intervention was in very old mice
Taron221 t1_j3qs71d wrote
>if this is something that works by injecting again (not saying it is), then it's exactly what pharma companies want, life extension by subscription.
If we aren't aging, then that just means they'll have to listen to us complain about the subscription over and over and over and over again. We'd have all the time in the world, lol.
Phoenix5869 t1_j3qwj2e wrote
This would translate to an extra 7.2 years (assuming the average lifespan is 80) if it worked in humans, which is something
WaitformeBumblebee t1_j3r1fx1 wrote
Didn't you read the terms of service? Any complaint may result in immediate cancellation without recourse.
Taron221 t1_j3r3edr wrote
Hmm, then every century we’ll draw straws or take new batches of world weary volunteers whose sole responsibility it will be to find new and creative ways to bully the Pharma CEOs. We’ll wear ‘em down eventually… That or we could just incessantly annoy politicians until it works, lol.
AndromedaAnimated t1_j3r4g43 wrote
It’s very interesting! A question though. Don’t they use the „black 6“ strain mice for that usually? Since they are already relatively long-lived (of my 6 lab pensioner „black 6“ mice, 4 are still alive and kicking after 2 years). They have black fur, not white/albino 😁
QwertzOne t1_j3r6v84 wrote
I wonder, if advances in quantum biology could provide some answers for solving cancer and aging: A quantum theory of disease, including cancer and aging .
I learned lately that quantum physics explains how a tadpole is able to turn into a frog, thanks to quantum tunneling.
Mokebe890 t1_j3r8er7 wrote
Both artificial general intelligence and quantum theories are wonderful but honestly I prefer to take them with dose of scepticism. We sure should research them but first turning to more classical explanation of aging, cancer and disease would be more practical and short term feasable.
moist_yoda t1_j3rhp4n wrote
So when can we buy genetically engineered rats that live up to 12 years? Pet rats live too short which sucks Because their such amazing animal.
Heap_Good_Firewater t1_j3rmxlu wrote
What a miraculous time to be alive (and also a mouse)!
UniversalMomentum t1_j3rtdma wrote
What happens when they get into the wild and breed like normal rats but live 4 times longer?
moist_yoda t1_j3rud3u wrote
Probably get killed by all the feral cats where I live.
meowingcauliflower t1_j3rueox wrote
That's the spirit!
CommunismDoesntWork t1_j3rwrk4 wrote
The kim dynasty shows no signs of stopping, even with deaths in the family.
Terowrath t1_j3shd8y wrote
Idk why you're getting downvoted, technology like this would 100% be exploited by the rich
myusernamehere1 t1_j3shj7n wrote
I doubt the gene alterations are heritable, unless they affect germ line cells
Black_RL t1_j3sm2dw wrote
Fix the code, fix the problem!
We’re just energy organized by code, once we dominate that, most problems should be gone.
VTX002 t1_j3som95 wrote
That remind me of something in a sci-fi book it called Prolong. And if anybody interested in what book is called honor Harrington series from the writer David Weber.
Thx4Coming2MyTedTalk t1_j3tt1zc wrote
Delivered it where? To what type/percentage of cells?
Blackmail30000 t1_j3ty43y wrote
Imagine having a hundred years to concoct a assassination plot.
Ghoullum t1_j3vcyr6 wrote
Wow, so many negative votes. Imagine that you go to the Altos investors (the most funded start up ever) and you tell them that their most promising technology will give them a 6% increase in longevity. They will be angry for sure haha. Caloric restriction has achieved in some cases up to 50% in some mammals... Rapa 20%. Acarbose close to 20%... IF 6% is the maximum we are going to get it is a big failure. I'm sorry all who are offended.
civilrunner t1_j3xioul wrote
Would be curious if whatever their cause of death received the same reprogramming or not. Simply removing one cause of age related death doesn't prolong life long since something else is normally close behind, you have to nearly do a full body reprogram which is far harder.
It will be interesting to learn more about the study.
[deleted] t1_j3xtkii wrote
[removed]
ChickenTeriyakiBoy1 OP t1_j3prtg2 wrote
>A small biotech company claims it has used a technology called reprogramming to rejuvenate old mice and extend their lives, a result suggesting that one day older people could have their biological clocks turned back with an injection—literally becoming younger.