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psychsafetyalliance OP t1_itsjney wrote

Reply to comment by psychsafetyalliance in We are Dax Jackson and Ally Lee of Psychedelic Safety Alliance. We are here to provide scientific, no-BS adult harm reduction education around psychedelics. by psychsafetyalliance

However, as far as we know, taking SSRIs with psilocybin does not cause serotonin syndrome. Taking way too much MDMA does, as can taking the supplement 5-HTP while on MDMA.

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deviltamer t1_itw7pof wrote

I know you guys put disclaimers in most of the posts and say as far as we know in this one but it's still short in caution,imo

TL:DR There's not enough evidence if psilocybin can cause serotonin syndrome with SSRIs

But no doubt the risk is dose, person AND SSRI drug dependent.

Almost all popular psychedelics target serotogenic pathways including psilocybin.

SSRIs increase serotonin synaptic availability and so do psilocybin but you're right some SSRIs will block psilocybin effects but others can produce dangerous multiplicative effects.

Please donot mix brain altering chemicals especially unsupervised. Permanent neural disability can and does happen albeit rarely.

More likely is you'll have a traumatic experience and be adrift from a tool that could have really helped you clinically.

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