Viewing a single comment thread. View all comments

deviltamer t1_itw7pof wrote

I know you guys put disclaimers in most of the posts and say as far as we know in this one but it's still short in caution,imo

TL:DR There's not enough evidence if psilocybin can cause serotonin syndrome with SSRIs

But no doubt the risk is dose, person AND SSRI drug dependent.

Almost all popular psychedelics target serotogenic pathways including psilocybin.

SSRIs increase serotonin synaptic availability and so do psilocybin but you're right some SSRIs will block psilocybin effects but others can produce dangerous multiplicative effects.

Please donot mix brain altering chemicals especially unsupervised. Permanent neural disability can and does happen albeit rarely.

More likely is you'll have a traumatic experience and be adrift from a tool that could have really helped you clinically.

1