Years ago NPR had this home cleaning expert on. She was asked how to maintain a clean house with a busy adult life. She said there were two paths and to pick one.

Path 1 - once a month take a whole day to clean. Clean the whole house and get it all done and spend the entire day if you need to. When the time comes to clean again your whole home will need it.

Path 2 - once a week you clean one room. Clean it thoroughly. Rotate rooms weekly and by the time that room's turn is up again it will need to be cleaned.