I think you are probably likely to get many biased answers about this because many people who live in Worcester have not lived in a different city, or moved from a more rural locale to Worcester. There is probably more crime than average in the Main South neighborhood, but if you have been in a different city before I would not say it is uniquely worse than any other slightly downtrodden midtown in a different city. On the upside park ave is rapidly developing and you will basically be in restaurant central where you are. If you already have good instincts for city life you will probably be fine.