beyardo t1_j94jip4 wrote
Reply to comment by LivingDegree in If a human being is bleeding internally say in their mouth or stomach would they still have a risk of anemia? by Robbeee
Should be noted that anemia of chronic disease is separate from chronic blood loss anemia, although IBD can cause both. Anemia of chronic disease is a result of chronic inflammation decreasing your body’s synthesis of RBCs, while blood loss anemia like that seen in chronic bleeding is a result of losing blood
Bax_Cadarn t1_j95fqtg wrote
That's why chronic disease is normocytic while with blood loss is microcytic. Unless with long term small bleeds the body adapts to eventually make them normal size too.
beyardo t1_j9anb0e wrote
ACD often eventually becomes microcytic as well, as the inflammatory stuff eventually sequesters the iron until you get a relative iron deficiency
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