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zk3033 t1_ja8ba9s wrote

A bit indirect, but some forms of achondroplasia are so severe that homozygotes are incompatible with live birth, and thus heterozygous (or homozygous would type) are the only observed.

A better example: ABO blood types in terms of blood contaminagion (whether available acceptable blood types, or maternal-fetal hemolytic anemia). Diversity of heterozygous actually works against a “phenotype” of immune acceptance.

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AlkalineHound t1_ja8uv38 wrote

This was the first thing I thought of. Another good example is a specific gene for hairlessness in dogs. It's dominant, so Hh would be hairless, but HH zygotes don't make it to birth.

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