Speaking of acetylcholine- anticholinergic drugs (such as tricyclic antidepressants, first-generation antihistamines, and bladder antimuscarinics) are significantly linked to early-onset dementia.

Taking an anticholinergic for the equivalent of three years or more was associated with a 54% higher dementia risk than taking the same dose for three months or less.

https://www.health.harvard.edu/blog/common-anticholinergic-drugs-like-benadryl-linked-increased-dementia-risk-201501287667

And, speaking of antihistamines- Benadryl. It’s criminal that it’s marketed for sleep and as “safe and non habit-forming”. It should NOT be taken regularly such as nightly for sleep, it is NOT safe and it IS habit forming/addictive. It’s so bad for you that in recreational drug communities it’s one of the number one things people tell others to stay away from.