> Legit, new genres like romance, thriller, drama, action

Well by that definition, it's definitely impossible. There are only so many different types of stories to tell about human beings, and those very broad genres pretty much cover it all.

But it's absolutely possible to create new sub-genres. Fiction based on a Earth that has undergone significant climate change is a growing one. Same with the often-dystopian settings in a high tech world, like the stories seen in the TV show Black Mirror.

Fanfiction is a genre not seen much in the past, popularized once the internet made it possible to easily share fanfiction with other fans of the same series.

While looking for more info I found an article mentioning "Gran Lit", romances or adventures featuring seniors rather than the usual young adults.