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Hapgam t1_j7w07a3 wrote

Glancing at the abstract as I don't access to the full article, but this study's population was very specific - "patients with extremity fractures that had been treated operatively or with any pelvic or acetabular fracture".

It would be interesting to see if aspirin continued to be noninferior in patients with conditions that were even more procoagulable, such as sepsis or covid. Does anyone happen to know if this is an active area of research being investigated in another conditions?

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sciolycaptain t1_j7wh7qj wrote

This study is in line with previous studies comparing aspirin to LMWH in this specific population of orthopedic trauma.

This was a larger number enrolled and showed low dose aspirin is non-inferior to LMWH for all cause mortality. But LMWH had lower instances of DVT and PE.

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SodaRayne t1_j7wpb7g wrote

> DVT and PE.

Deep Vein Thrombosis and Pulmonary Edema?

edit: That's what I get for reading the comments before the article. Deep venous thromboembolism (DVT) is listed in the first sentence.

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ThreeBlindRice t1_j7wtpzq wrote

Pulmonary embolism*.

Venous thromboembolism (VTE) is the better umbrella term.

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SodaRayne t1_j7wwbwp wrote

Thank you. Yeah, not sure why my brain jumped to edema, given the topic. Crossed wires I guess, but then that's also why I like to confirm initialisms.

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AnnexBlaster t1_j7wmgtr wrote

Yes I do research on the effects of anticoagulant drugs for sepsis, but I haven’t investigated aspirin yet, I suspect though that the toxins in sepsis cause far too much platelet activation for aspirin to handle, ticagrelor on the other hand looks very promising for increasing platelet killing efficiency and host survival.

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memetunis t1_j7x7838 wrote

I go to a clinic to have my port flushed, which is done with heparin. Each room has a sign stating they don't store large amounts of heparin on site, similar to what you see with opioids. Do you know why this would be? I have asked the nurses but they weren't aware.

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BuggerMyElbow t1_j7y68tl wrote

What are the toxins involved in sepsis and where do they come from?

I'd imagine they come from the bacteria, so lipopolysaccharides/endotoxin? Are these responsible for platelet malfunction?

Also how does sepsis vary depending on the species and strain of bacteria?

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AnnexBlaster t1_j7yevf3 wrote

Theres proteins in Staph aureus called clumping factors which active platelets, and pore forming exotoxins called alpha hemolysins which cause major damage.

Sepeis varies a great deal between bacteria, the toxins from different pathogens determine whether your immune system will win, or how fast and painful your death will be

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Balthasar_Loscha t1_j8syjub wrote

Aspirin as a preventative for COVID-related clotting in a male? Not your area, but maybe you heard something?

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AnnexBlaster t1_j8t1s90 wrote

Yes theres studies about this, I think its better than not taking a preventative drug. I want to see a paper about it preventing long covid

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robm111 t1_j7wt81o wrote

Interested in this also. I was diagnosed with a genetic blood clotting disorder right when I turned 40, being told I have to be on a very expensive blood thinner for the rest of my life was... not great to hear. (Though obviously better than dead.)

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mwebster745 t1_j86pk5s wrote

Gotta say working on an anticoagulation clinic I'm really hoping my patients I need to bridge off warfarin with a LMWH don't think this applies to them. The title is a bit overgeneralized, like you said, very specific population

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