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The-Crawling-Chaos t1_j8u9m24 wrote

Reply to comment by rjmsci in Psychedelics activate the same receptors as serotonin, so why aren't we always tripping? Psychedelics may cause neuronal plasticity and relieve depression by activating intracellular serotonin receptors that serotonin itself cannot, suggests a new study. by rjmsci

> Depression is not caused by lowered serotonin activity, sure, but compounds that primarily modulate the serotonin system do relieve it.

Which isn’t surprising when their response rate is only ~10% higher than the placebo- controlled response rates for depression of ~40% on average.

source 1 Source 2 Source 3 (another Moncrieff)

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