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km89 t1_j8ukh6r wrote

Reply to comment by bannedPosts in Psychedelics activate the same receptors as serotonin, so why aren't we always tripping? Psychedelics may cause neuronal plasticity and relieve depression by activating intracellular serotonin receptors that serotonin itself cannot, suggests a new study. by rjmsci

Coming from a place of total ignorance here, is there any explanation for why SSRIs work so well, assuming serotonin isn't correlated with depression?

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AeonDisc t1_j8v0vnw wrote

Isn't the success rate of treating depression with SSRI's actually rather low?

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69tank69 t1_j8uqnie wrote

We don’t fully know. But some research has gone into looking at serotonin boosting Neuro plasticity with conventional anti depressants triggering the 5HT1A. Unfortunately checking mechanisms deep in the brain are very difficult to do but if your interested in that side I would consider reading some articles on the Neuro plasticity hypothesis of depression

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bannedPosts t1_j8ytvrk wrote

There's no explanation - aside from wishful thinking - SSRIs do not work any better than placebo. In fact, the most reliable predictor of efficacy is believing they will work. If your doc can sell it, it might work. Sounds like religion to me. If, and I say if, SSRIs worked as advertises they would work in a few days not months / years. No other class of drugs enjoys more apologists than SSRIs.

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km89 t1_j8yvud9 wrote

I would very much like to see data on this.

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ERSTF t1_j90l9bf wrote

I did not know this. Would love to see the data. As an ignorant myself. What is best for treating depression?

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