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KnightCreed13 t1_ir9ixzc wrote

Reply to comment by Antique-Painting-627 in Mitochondrial DNA Is Working Its Way Into the Human Genome by molrose96

Well why tf is it doing that?

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Darkhorseman81 t1_ir9o901 wrote

Some Viruses want to avengers assemble. Ask cytoskeletal ARC why. It's responsible for the efficiency of human long term memory, but started as an ancient aids like virus.

I'm sure there are many other examples.

You can reverse amnesia by stimulating arc protein expression. Chems like Withanolides stimulate it.

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catty_big t1_iravqab wrote

Amnesia, of course! I knew there was something I wanted to try to reverse. Now if only I could remember what that thing was I wanted to try to reverse.

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mrsmoose123 t1_ir9pw82 wrote

This so cool! How plants work as medicine in our bodies seems to be getting a better evidence base.

How are we able to find things like this out? I'm aware genetic sequencing is involved, but it baffles me how we know which proteins do what.

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danielravennest t1_ir9ws4q wrote

> it baffles me how we know which proteins do what.

Mice have 85% of the same DNA as we do. So-called "knockout mice" have bits of DNA removed, then they see what problem removing it causes.

The other approach is finding an antigen that blocks the particular protein, then see what happens.

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BiggWigg92 t1_irc2721 wrote

Can ypu elaborate on that or share a good source to read up on that please?

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Lvl100Glurak t1_ir9zgds wrote

so mitochondria are weak creatures and they know. so instead of becoming strong themselves, they offered help to strong creatures. this seemed very kind, but in reality they're playing the long game and soon they overtake those strong creatures, as the strong creatures are 100% dependent on the ATP mitochondria produce. they're like the hidden elite in our bodies.

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adamtheskill t1_irayald wrote

Probably just because it's possible, it's not like the dna has a goal. It's just pure chance and if any changes increase the chance of dna getting passed on they will persist. It's not like a higher chance of getting cancer in old age has any effect on how many children a person has on average.

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rephaim_ t1_irb9cdk wrote

Getting into more genomes is an endgame. There are viruses fossilized in our genomes, it's good for the virus because it's dna gets passed on with no additional work, and it's good for the host because that virus won't trigger immune responses since it's now recognized as part of the host.

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