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tornpentacle t1_ixzryml wrote

Reply to comment by gospdrcr000 in Decarboxylation of cannabidiolic acid (CBDA) is an important step for efficient production of the active pharmaceutical component cannabidiol (CBD) in Cannabis species. Acidic cannabinoids (ACBs) can be easily transformed into neutral cannabinoids via loss of carbon dioxide when exposed to heat by The_R3venant

Well, OP didn't use the actual title of the paper. This goes into the chemistry of it. It is very well known that heat decarboxylates cannabinoids. Perhaps not as well known (not popularly, nor in the literature) are the specifics of the chemical changes that occur, which molecular bonds break, what other byproducts are created, etc.

From the abstract:

>In particular, most of the CBDA was converted into CBD at 130 °C for 20 min; this CBD was partially transformed to psychotropic THC isomers via cyclization. In addition to THC isomers, cannabielsoin acid (CBEA) and cannabielsoin (CBE) were also observed as minor oxidative transformed products. Based on structural identification and profiling data, thermal transformation pathways of CBDA are plausibly suggested. The results of decarboxylation of ACBs will provide important information on production of neutral cannabinoids, especially CBD, in Cannabis plants and quality control of Cannabis-based products in pharmaceutical and cosmetic industries.

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